Innovation in Health Care

Global Equities

Innovation in Health Care

What are the key themes likely to shape markets in 2019?

I believe innovation will be a driving force for health care stocks in 2019. Over the past two years, the U.S. Food and Drug Administration (FDA) approved more than 90 novel therapies. These products, still early in their launch phase, could drive industry growth for years to come.

Many new therapies represent revolutionary advances in medicine. Immunooncology medicines, for one, harness the immune system to target and attack cancer cells, often with impressive results. Exciting advances are being made in gene therapies that address rare and debilitating diseases. The first gene therapy was approved in the U.S. in late 2017, and we expect additional approvals as soon as next year. Advances are also being made in medical devices, where the first integrated continuous glucose monitor for diabetes management recently won FDA approval and positive clinical trial data were presented for mitral valve repair and drug-eluting stents. Finally, a consolidation in services is leading to more integrated health care services companies.

Where do you see the most important opportunities and risks within your asset class?

Drug pricing reform in the U.S. remains a concern for the health care sector, as President Trump has made lowering consumers’ out-of-pocket drug costs a priority. Amazon’s recent acquisition of an online pharmacy could also lead to disintermediation of the drug-supply chain. Broadly, we believe reforms that remove inefficiencies and improve patient affordability are good for the system in the long term. As always, we also have to think about the binary nature of drug development. For as many drugs that get regulatory approval, a multitude of others never make it out of clinical trials, leading to volatility.

How have your experiences in 2018 shifted your approach or outlook for 2019?

In our opinion, remaining disciplined on valuation in 2018 was critical to managing downside volatility. During the summer, we saw a high level of investor enthusiasm for early-stage biotechnology companies, even though fundamentals did not always support elevated valuations, in our opinion. When the broad equity market declined in October, many of these stocks had the farthest to fall. Consequently, we remain committed to taking a balanced approach, investing across the health care sector’s major subindustries, market capitalizations and geographies.

But overall, our enthusiasm for the sector has never been higher. In addition to companies delivering medical breakthroughs, regulators globally have shown their commitment to quickly bringing treatments to market for patients with high, unmet medical needs. With new drugs and medical devices in the process of launching – and major patent cliffs largely behind us – we believe this is a sweet spot for many areas of the sector.

Sequencing the Human Genome

A dramatic fall in DNA sequencing costs is helping drive innovation in health care.

Sequencing the Human Genome | Market GPS | Janus Henderson

Source: Human Genome Research Institute, as of 7/31/17

Key Themes
Disruption Theme Small Icon | Janus Henderson Investors

Disruptive Forces

"Over the past two years, the U.S. Food and Drug Administration approved more than 90 novel therapies. These products, still early in their launch phase, could drive industry growth for years to come." - Andy Acker, CFA, Portfolio Manager


Global Life Sciences Fund

Global health care fund balanced across pharmaceuticals, biotech and services/devices sub-sectors that seeks to achieve outperformance over benchmark and peers.

What else do our experts see for the year ahead?

Staying Focused on Secular Growth
As interest rates and inflation pressures climb, Portfolio Manager Doug Rao says it is becoming all the more important to focus on companies with secular tailwinds, pricing power and competitive advantages.

The Dawn of a More-Connected, Data-Driven World
Portfolio Manager Denny Fish believes the mega-themes positioned to drive sector earnings in the years to come will continue to gain market share as companies place digital transformation at the center of their business strategy.